ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Dux Activates Metabolism-Lactylation-MET Network during Early iPSC Reprogramming with Brg1 as the Histone Lactylation Reader

[Nucleic Acids Research] Scientists demonstrated that the modification of H3K18la induced by Dux overexpression controlled the metabolism-H3K18la-MET network, enhancing the efficiency of iPSC reprogramming through a metabolic switch and the recruitment of p300 via its C-terminal domain.

Preparation of Human Astrocytes with Potent Therapeutic Functions from Human Pluripotent Stem Cells Using Ventral Midbrain Patterning

[Journal of Advanced Research] To substantiate the clinical application of astrocyte-based therapy, researchers prepared human astrocytes with potent therapeutic capacities from hPSCs. They used ventral midbrain patterning during the differentiation of hPSCs into astrocytes.

Matrix-Free Human Pluripotent Stem Cell Manufacturing by Seed Train Approach and Intermediate Cryopreservation

[Stem Cell Research & Therapy] Stirred tank bioreactors-controlled, chemical aggregate dissociation, and optimized passage duration of three or four days promoted exponential hPSC proliferation, process efficiency, and upscaling by a seed train approach.

Spatial Cell Fate Manipulation of Human Pluripotent Stem Cells by Controlling the Microenvironment Using Photocurable Hydrogel

[Development] Investigators cultured hPSCs on hydrogel substrates with spatially controlled stiffness. The use of culture substrates that enabled precise manipulation of spatial mechanical properties held promise for better mimicking in vivo conditions and advancing tissue engineering techniques.

Diverting the Food-Freezing Technology Improves the Cryopreservation Efficiency of Induced Pluripotent Stem Cells and Derived Neurospheres

[Regenerative Therapy] Scientists evaluated the efficiency of cryopreservation using DEPAK and Proton freezers, both of which are used in the food industry, compared with conventional slow-freezing methods using a programmable freezer and a cell-freezing vessel.

Rbm46 Inhibits Reactive Oxygen Species in Mouse Embryonic Stem Cells through Modulating BNIP3-Mediated Mitophagy

[Biochemical and Biophysical Research Communications] The authors revealed the pivotal role of RNA-binding motif protein 46 (RBM46) in ESCs, acting as a direct post transcriptional regulator of ROS levels by modulating BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) mRNA expression.

Conditioned Medium of Induced Pluripotent Stem Cell Derived Neuromesodermal Progenitors Enhances Cell Migration In Vitro

[Molecular Biology Reports] Neuromesodermal progenitors (NMPs) derived from iPSCs were used to collect conditioned medium. Fibroblast derived iPSCs were successfully differentiated into NMPs and NMPs were characterized by double positive T/Bra and Sox2 staining.

From Pluripotent Stem Cells to Organoids and Bioprinting: Recent Advances in Dental Epithelium and Ameloblast Models to Study Tooth Biology and Regeneration

[Stem Cell Reviews and Report] Scientists evaluate the current state-of-the-art regarding in vitro cell culture models of dental epithelium and ameloblast lineage with a particular focus toward their applicability for translational tissue engineering and regenerative/personalized medicine.

Stem Cell Models of Inherited Arrhythmias

[Nature Cardiovascular Research] Investigators review the current state of knowledge surrounding the cellular mechanisms of inherited arrhythmias generated from stem cell models with a focus on integrating genetic and mechanistic data.

UMass Chan and Lahey Partner on New Clinical and Quantitative Research Science Hub

[UMass Chan Medical School] UMass Chan Medical School and Lahey Hospital & Medical Center have signed a research affiliation agreement to create a new quantitative science research hub to improve health outcomes and disparities through population health, digital medicine and health systems science.

H3K4me1 Facilitates Promoter-Enhancer Interactions and Gene Activation during Embryonic Stem Cell Differentiation

[Molecular Cell] To better understand the role of H3K4me1 in enhancer function, the authors analyzed dynamic enhancer-promoter interactions and gene expression during neural differentiation of the mESCs.

Directed Differentiation of Human Embryonic Stem Cells into Parathyroid Cells and Establishment of Parathyroid Organoids

[Cell Proliferation] Transcriptome, differentiation marker protein detection and parathyroid hormone secretion assays were performed after the completion of the in vitro differentiation of parathyroid-like cells.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.

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