ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Subscribe|Follow Us On

Annelid Adult Cell Type Diversity and Their Pluripotent Cellular Origins

April 15, 2024

[Nature Communications] Researchers recovered 75,218 single cell transcriptomes of the highly regenerative and asexually-reproducing annelid Pristina leidyi.

Generation of Two iPSC Lines From Patients with Inherited Central Core Disease and Concurrent Malignant Hyperthermia Caused by Dominant Missense Variants in the RYR1...

April 10, 2024

[Stem Cell Research] Scientists generated iPSC lines from two patients with central core disease and malignant hyperthermia caused by dominant RYR1 variants within the central region of the protein. Both lines displayed typical iPSC morphology, uniform expression of pluripotency markers, trilineage differentiation potential, and had normal karyotypes.

Basal Delamination During Mouse Gastrulation Primes Pluripotent Cells for Differentiation

April 10, 2024

[Developmental Cell] The authors developed and characterized a 3D culture of self-renewing mouse embryonic cells that captures the main transcriptional and architectural features of the early gastrulating mouse epiblast.

The Effect of Trisomic Chromosomes on Spatial Genome Organization and Global Transcription in Embryonic Stem Cells

April 10, 2024

[Cell Proliferation] How aneuploidy affects spatial genome organization remains poorly understood. Researchers addressed this question by utilizing the previously established isogenic wild-type (WT) and trisomic mouse embryonic stem cells

Little Change in Japan’s Research Sector 10 Years after Stem Cell Fraud

April 10, 2024

[The Japan Times] Ten years after the STAP stem cell scandal, structural problems that led to the scandal persist, leaving ample room for researchers to tamper with research data, experts say.

Reconstructing Axial Progenitor Field Dynamics in Mouse Stem Cell-Derived Embryoids

April 9, 2024

[Developmental Cell] Investigators combined continuous Cas9-based molecular recording with a mESC-based model of the embryonic trunk to build single-cell phylogenies that described the behavior of transient, multipotent neuro-mesodermal progenitors as they committed into neural and somitic cell types.

Human iPSC 4R Tauopathy Model Uncovers Modifiers of Tau Propagation

April 9, 2024

[Cell] The authors engineered hiPSC-derived neuronal lines to express 4R Tau and 4R Tau carrying the P301S MAPT mutation when differentiated into neurons.

The Dynamic Landscape of Enhancer-Derived RNA during Mouse Early Embryo Development

April 9, 2024

[Cell Reports] Scientists presented a comprehensive eRNA atlas by systematically integrating publicly available datasets of mouse early embryos. They characterized the transcriptional and regulatory network of eRNAs and showed that different embryo developmental stages had distinct eRNA expression and regulatory profiles.

Substrate Elasticity Does Not Impact DNA Methylation Changes during Differentiation of Pluripotent Stem Cells

April 9, 2024

[Cytotherapy] The authors cultured iPSCs on tissue culture plastic and polydimethylsiloxane with different Young's modulus to investigate the sequel on growth and differentiation toward endoderm, mesoderm, and ectoderm.

Clinical Translation of Pluripotent Stem Cell-Based Therapies: Successes and Challenges

April 9, 2024

[Development] Investigators highlight successes from some of the hPSC-based trials reporting early signs of efficacy and discuss common challenges in clinical translation of cell therapies.

MAGIK: A Rapid and Efficient Method to Create Lineage-Specific Reporters in Human Pluripotent Stem Cells

April 8, 2024

[Stem Cell Reports] Researchers presented the modified mRNA (ModRNA)-based Activation for Gene Insertion and Knockin (MAGIK) method. MAGIK operated in two steps: first, it used a Cas9-2A-p53DD modRNA with a mini-donor plasmid; second a deactivated Cas9 activator modRNA and a 'dead' guide RNA were used to temporarily activate the targeted gene.

Oct4 Controls Basement Membrane Development during Human Embryogenesis

April 8, 2024

[Developmental Cell] Using the post-implantation amniotic sac embryoid, scientists delineated basement membrane (BM) assembly upon post-implantation development and BM disassembly during primitive streak cell dissemination.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.