Volume 5.42 | Oct 27

ESC & iPSC News 5.42, October 27, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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SIRT1 Deficiency Compromises Mouse Embryonic Stem Cell Hematopoietic Differentiation, and Embryonic and Adult Hematopoiesis in the Mouse 
Researchers examined hematopoietic and endothelial cell differentiation of SIRT1-/- mouse embryonic stem cells in vitro, and hematopoietic progenitors in SIRT1+/+, +/-, and -/- mice. [Blood]

Defining Characteristics of Bona Fide Human iPS Cells
Speaker: Sutheera Ratanasirintrawoot, PhD Candidate
G. Daley & T. Schlaeger Labs, Harvard Medical School


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New High-Content Assay to Increase Human Embryonic Stem Cell Survival
Researchers from the Universities of Dundee, Glasgow and Heriot-Watt University, Edinburgh, have produced a high-content assay for human embryonic stem cell survival and used this to screen a range of libraries of ‘lead-like’ small molecules and known bioactives. [Press release from The Medical News discussing online prepublication in the Biochemical Journal]
Bioelectrical Signals Turn Stem Cells’ Progeny Cancerous
Biologists have discovered that a change in membrane voltage in newly identified “instructor cells” can cause stem cells’ descendants to trigger melanoma-like growth in pigment cells. The team also found that this metastatic transformation is due to changes in serotonin transport. [Press release from Tufts University discussing online prepublication in Disease Models and Mechanisms]
Scientists Create Australia’s First Diabetes Cells
In a major research advance, Melbourne researchers have created Australia’s first type 1 diabetes cells. Researchers created the diabetes cells using induced pluripotent stem cell technology. [Monash Institute of Medical Research Press Release]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Integrated Biochemical and Mechanical Signals Regulate Multifaceted Human Embryonic Stem Cell Functions
Feedback regulation and mechanical-biochemical integration provide mechanistic insights for the regulation of intercellular adhesion and cellular architecture in embryonic stem cells during long-term self-renewal. [J Cell Biol]
Genome-Wide Identification of Targets and Function of Individual MicroRNAs in Mouse Embryonic Stem Cells
Data suggest that miR-294 may promote pluripotency by regulating a subset of c-Myc target genes and upregulating pluripotency-associated genes such as Lin28. [PLoS Genet]

Production of Functional Glucagon-Secreting Alpha Cells from Human Embryonic Stem Cells
Results indicate that fully differentiated pancreatic endocrine cells can be created via step-wise differentiation of human embryonic stem cells. [Diabetes]

Somatic Cell Nuclear Reprogramming of Mouse Oocytes Endures Beyond Reproductive Decline
Researchers show that oocytes isolated from mice aged beyond the usual reproductive age yield ooplasts that retain reprogramming capacity after somatic nuclear transfer, giving rise to higher blastocysts rates compared to young donors ooplasts. [Aging Cell]
High-Content Screening of Feeder-Free Human Embryonic Stem Cells to Identify Pro-Survival Small Molecules
Researchers have developed a high-content assay for human embryonic stem cell survival and used this to screen a range of libraries of ‘lead-like’ small molecules and known bioactives. [Biochem J]
Human Pluripotent Stem Cells Produce Natural Killer Cells That Mediate Anti-HIV-1 Activity Utilizing Diverse Cellular Mechanisms
Researchers demonstrate derivation of functional natural killer (NK) cells from human induced pluripotent stem cells (iPSCs). More importantly, both human embryonic stem cell- and iPSC-derived NK cells are able to inhibit HIV-1 NL4-3 infection of CEM-GFP cells. [J Virol]

Nanofiber Matrices Promote the Neuronal Differentiation of Human Embryonic Stem Cell Derived-Neural Precursors In Vitro
Researchers cultured human neural precursors (NPs) derived from the NIH-approved embryonic stem line BGO1 on polycaprolactone fiber matrices of different diameter (i.e. nanofibers and microfibers) and orientation (i.e. aligned and random); fibers were coated with poly-L-ornithine/laminin to mimic the extracellular matrix and support the adhesion, viability and differentiation of NPs. [Tissue Eng Part A]
Transmembrane Potential of GlyCl-Expressing Instructor Cells Induces a Neoplastic-Like Conversion of Melanocytes via a Serotonergic Pathway
Data reveal glycine receptor chloride channel (GlyCl) as a molecular marker of a sparse and heretofore unknown cell population with the ability to specifically instruct neural crest derivatives, suggest transmembrane potential as a tractable signaling modality by which somatic cells can control stem cell behavior at considerable distance, identify a new biophysical aspect of the environment that confers a neoplastic-like phenotype upon stem cell progeny, reveal a pre-neural role for serotonin and its transporter, and suggest a novel strategy for manipulating stem cell behavior. [Dis Models Mech]

Enhanced Reprogramming and Cardiac Differentiation of Human Keratinocytes Derived from Plucked Hair Follicles, Using a Single Excisable Lentivirus
Researchers describe a detailed and reproducible method to derive induced pluripotent stem cells (iPSCs) from plucked human hair follicle keratinocytes. All emerging colonies were true iPSCs, with characteristics typical of human embryonic stem cells, differentiated into derivatives of all three germ layers in vitro and in vivo. [Cell Reprogram]


Cellectis and the Center for iPS Cells Research and Application Enter Collaboration
Cellectis and the Center for iPS Cells Research and Application (CiRA) of Kyoto University have announced that they have started a scientific collaboration to combine Cellectis’ genome engineering technologies with CiRA’s induced pluripotent stem cell (iPS) technology to improve the natural characteristics of iPS cells for use as cellular tools. [Cellectis Press Release]

Sanofi-aventis Announces Expiration of Hart-Scott-Rodino Waiting Period for Acquisition of Genzyme
Sanofi-aventis announced that the waiting period under the Hart-Scott Rodino Antitrust Improvements Act of 1976, as amended, applicable to Sanofi-aventis’ proposed acquisition of Genzyme Corporation has expired. [Sanofi-aventis Press Release]

CIRM Funds $72 Million to Translate Basic Discoveries into New Therapies, Recruit Stem Cell Leaders to California
The California Institute for Regenerative Medicine (CIRM) approved funding for 19 awards worth $67 million in its second round of awards designed to move good ideas out of the lab and into the clinic. [The California Institute for Regenerative Medicine Press Release]
Over 400 Top Researchers Selected in the European Research Council’s Third Prestigious ‘Starting Grant’ Competition
The European Research Council is awarding some EUR 580 million to 427 early career top researchers in its competition for ‘Starting Grants’. Worth up to EUR 2 million each, the grants will enable them to carry out their pioneering ideas in any field of research, throughout Europe. [European Research Council, European Union]

Combining Stem Cell and Gene Therapy Techniques to Tackle a Deadly Blood Disease
The National Institutes of Health has awarded a three-year, $3.9 million grant to Children’s Hospital Boston researchers and their colleagues to develop a therapy to treat Fanconi anemia. [Children’s Hospital Boston Press Release]
Stem Cell Central: The Lorry I. Lokey Building
The Lokey Building, an incredible new laboratory facility, is built on a design championed by faculty to facilitate research in one of the most exciting interdisciplinary areas of the 21st century — stem cell biology and regenerative medicine. [Stanford University School of Medicine Press Release]


NIH Supporters Line Up to File Legal Stem Cell Arguments
Numerous friends of human embryonic stem cell research are lining up to support the National Institutes of Health (NIH) in a major court case challenging the agency’s ability to fund the research. [National Institutes of Health, United States]
NIH Recovery Act Grants to Foster Scientific Workforce Diversity
The National Institutes of Health (NIH) has awarded six grants totaling approximately $12 million over three years through a new initiative aimed at fostering a diverse scientific workforce. [National Institutes of Health, United States]
NIH Recovery Act Awards Enable Crucial Health Research Technologies
Thanks to the Recovery Act, more health scientists now will have access to state-of-the-art devices, the National Institutes of Health (NIH) announced. Through its National Center for Research Resources, NIH has awarded $300 million in shared instrumentation grants. [National Institutes of Health, United States]

White House Science Office Sued Over ‘Scientific Integrity’ Docs
Public Employees for Environmental Responsibility has filed a lawsuit seeking an explanation for why the Obama Administration is 18 months late on delivering its promised guidelines on scientific integrity for the federal government. [Public Employees for Environmental Responsibility, United States]

Just a Flesh Wound? U.K. Science Budget Spared Deep Cuts
The U.K. government’s long-awaited Comprehensive Spending Review was released, and it calls for a flat science budget over the next 4 years. While inflationary costs mean that the budget will likely see a cut of about 10% in real terms over that period, this scenario is far less dramatic than rumored cuts of 20% to 30% in real cash. [HM Treasury, United Kingdom]
Cellular, Tissue and Gene Therapies Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]
Guidelines for Use of Stored Specimens and Access to Ancillary Data and Proposed Cost Schedule: Stored Biologic Specimens and Ancillary Data From the Collaborative Perinatal Project (CPP) (FR Doc. 2010-27183) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27192) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27185) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-27049) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27040) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-27039) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-26935) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26881) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26499) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26497) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-27187) [National Institutes of Health, United States]


Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

5th UK Cancer Stem Cell Symposium
November 2, 2010
London, United Kingdom

BioMalaysia 2010 Conference and Exhibition
November 1-3, 2010
Kuala Lumpur, Malaysia

Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
November 2-3, 2010

NEW In Vitro Toxicology Society Annual Meeting
November 2-3, 2010
Liverpool, United Kingdom

NEW Third Annual Research Experience of Stem Cells in European (RESCUE) Society Conference
November 8-9, 2010
Oxford, United Kingdom

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

8th Annual Commercial Translation of Regenerative Medicine Conference
November 18-19, 2010
London, United Kingdom

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

NEW Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

Biotech Showcase 2011
January 10-12, 2011
San Francisco, United States

Select Biosciences 5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Keystone Symposia-Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Molecular Medicine Tri-Conference – Stem Cells: Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Dillon, United States

NEW United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


Lab Technologist — Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

Lab Technologist — Tissue Culture (STEMCELL Technologies)

Product Manager — Pluripotent Stem Cells (STEMCELL Technologies)

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