Volume 6.47 | Nov 30

ESC & iPSC News 6.47, November 30, 2011
ESC & iPSC News
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Scientists Lead Human Embryonic Stem Cell Study to Advance the Field of Regenerative Medicine Research
Researchers took roles in a study that identified a portion of the genome mutated during long-term culture of human embryonic stem cells. [Press release from the Agency for Science, Technology and Research discussing online prepublication in Nature Biotechnology] Press Release | Abstract

Use AggreWell™ for Reproducible, Uniform Embryoid Bodies
PUBLICATIONS (Ranked by Impact Factor of the Journal)
Excitation-Induced Ataxin-3 Aggregation in Neurons from Patients with Machado–Joseph Disease
Researchers show that l-glutamate-induced excitation of patient-specific induced pluripotent stem cell-derived neurons initiates Ca2+-dependent proteolysis of ataxin 3 followed by the formation of SDS-insoluble aggregates. [Nature] Abstract | Press Release

Mouse B-Type Lamins Are Required for Proper Organogenesis but Not by Embryonic Stem Cells
Investigators found that mouse embryonic stem cells do not need any lamins for self-renewal and pluripotency. [Science] Abstract | Press Release

Donor Cell Type Can Influence the Epigenome and Differentiation Potential of Human Induced Pluripotent Stem Cells
Investigators compared bona fide human induced pluripotent stem cells derived from umbilical cord blood cells and neonatal keratinocytes. [Nat Biotechnol] Abstract

Using iPSC-Derived Neurons to Uncover Cellular Phenotypes Associated with Timothy Syndrome
Researchers generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells (iPSCs) derived from individuals with Timothy syndrome. [Nat Med] Abstract | Press Release

The Quantitative Proteomes of Human-Induced Pluripotent Stem Cells and Embryonic Stem Cells
Here, scientists present an in-depth quantitative mass spectrometry-based analysis of human embryonic stem cells, two different human-induced pluripotent stem cells and their precursor fibroblast cell lines. [Mol Syst Biol] Abstract

Regulated Expression and Role of c-Myb in the Cardiovascular-Directed Differentiation of Mouse Embryonic Stem Cells
The objective of this study is to define the role of c-Myb in smooth muscle cell differentiation from embryonic stem cells. [Circ Res] Abstract

The Differentiation and Isolation of Mouse Embryonic Stem Cells Toward Hepatocytes Using Galactose-Carrying Substrata
In this study, researchers report the effect of a matrix-dependent enrichment of embryonic stem cell-derived hepatocytes using immobilized poly(N-p-vinylbenzyl-4-O-β-d-galactopyranosyl-d-gluconamide) with E-cadherin-IgG Fc as a galactose-carrying substratum. [Biomaterials] Abstract

Generation of Mouse ES Cell Lines Engineered for the Forced Induction of Transcription Factors
Here investigators report the generation and characterization of 84 mouse embryonic stem cell lines with doxycycline-controllable transcription factors (TFs) which, together with the previous 53 lines, cover 7–10% of all TFs encoded in the mouse genome. [Sci Rep] Abstract

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Second U.S. Patent Awarded to Stem Cell Idea of Kyoto University’s Yamanaka
The United States has awarded a patent for Kyoto University professor Shinya Yamanaka’s technology for creating induced pluripotent stem cells, the second of its kind since the first patent for the technique was granted in August. [Mainichi Daily] Press Release

Sanford Consortium Opens New “Collaboratory”: First of Its Kind Stem Cell Science Facility Will Harness Intellectual Capital of Five World-Class Research Institutions
The Sanford Consortium for Regenerative Medicine opened a new collaborative research building, formally launching California’s newest facility dedicated to stem cell science. [Sanford Consortium for Regenerative Medicine] Press Release
Lab Bred Chimps Despite Ban
The largest and most high-profile chimpanzee research center in the United States has acknowledged that 137 infant chimpanzees have been born to federally owned animals under its care since 2000, despite a government moratorium on such births. [New Iberia Research Center, United States] Press Release

Budget Cuts Threaten Denmark’s Science Assessment Body
The Parliament is expected to pass a bill to begin the process of eliminating the Danish Board of Technology as part of a 3% cut in the country’s 2012 research budget. [Danish Parliament, Denmark] Press Release

First EU Chief Scientific Adviser Named
Europe’s first chief scientific adviser (CSA) is to be Anne Glover. Glover is a molecular and cell biologist and is Scotland’s CSA at present. [European Commission, European Union (EU)] Press Release
NEW Keystone Symposia: The Life of a Stem Cell: From Birth to Death
March 11-16, 2012
Olympic Valley, United States

our events page to see a complete list of events in the ESC & iPSC community.

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral Positions (National Centre for Biological Sciences)

PhD Studentship in Stem Cells and Regenerative Medicine (King’s College London)

Scientist – Differentiation Segment (Stemgent, Inc.)

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