Volume 7.11 | Mar 21

ESC & iPSC News 7.11, March 21, 2012
ESC & iPSC News
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Stem Cells Hint at Potential Treatment for Huntington’s Disease
Scientists have learned how to make large amounts of GABA neurons from human embryonic stem cells, which they sought to test in a mouse model of Huntington’s disease. [Press release from the University of Wisconsin-Madison discussing online prepublication in Cell Stem Cell] Press Release | Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)
Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells
Researchers validated 27 antibodies against lineage-specific cell-surface markers, which enabled investigation of specific cell populations during embryonic (ES)-epiblast reprogramming and ES-to-extraembryonic endoderm differentiation. [Dev Cell] Abstract

Arrayed Cellular Microenvironments for Identifying Culture and Differentiation Conditions for Stem, Primary and Rare Cell Populations
Investigators describe a technology, referred to as arrayed cellular microenvironments, that allows for a high-throughput examination of the effects of multiple extracellular components in a combinatorial manner on any cell type of interest. They specifically focus on the application of this technology to human pluripotent stem cells. [Nat Protoc] Abstract

Generation of Induced Pluripotent Stem Cells from a Small Amount of Human Peripheral Blood Using a Combination of Activated T Cells and Sendai Virus
Scientists present a detailed protocol for the generation of induced pluripotent stem cells (iPSCs) from a small amount of human peripheral blood using a combination of activated T cells and mutant Sendai virus encoding human OCT3/4, SOX2, KLF4 and c-MYC; T cell–derived iPSCs can be generated within 1 month of blood sampling. [Nat Protoc] Abstract

Unveiling Combinatorial Regulation through the Combination of ChIP Information and In Silico Cis-Regulatory Module Detection
Researchers show that exploiting ChIP-information in a query-based way makes in silico cis-regulatory module (CRM) detection a much more feasible endeavor. By applying it on a well-studied ChIP-Seq data set involved in self-renewal of mouse embryonic stem cells, they demonstrate how their tool can recover combinatorial regulation of five known transcription factors that are key in the self-renewal of mouse embryonic stem cells. [Nucleic Acids Res] Abstract

A ZFN/Piggyback Step Closer to Autologous Liver Cell Therapy
Investigators show that a combination of zinc finger nucleases (ZFNs) and piggyback technology in human induced pluripotent stem cells can achieve bi-allelic correction of a point mutation (Glu342Lys) in the α1-antitrypsin gene that is responsible for α1-antitrypsin deficiency. [Hepatology] Abstract

The Endogenous Retrovirus ENS-1 Provides Active Binding Sites for Transcription Factors in Embryonic Stem Cells that Specify Extra Embryonic Tissue
Scientists show that Ens-1 long terminal repeat activity is controlled by two transcriptional pathways that drive pluripotent cells to alternative developmental fates. [Retrovirology] Abstract

Gene Expression Signatures Defining Fundamental Biological Processes in Pluripotent, Early and the Late Differentiated Embryonic Stem Cells
Investigators have made an attempt to understand differentiation networks controlling embryogenesis in vivo using a time kinetic, and by identifying molecules defining fundamental biological processes in the pluripotent state as well as in early and the late differentiation stages of embryonic stem cells. [Stem Cells Dev] Abstract

Tracing the Conversion Process for Primordial Germ Cells to Pluripotent Stem Cells in Mice
To understand mechanisms underlying acquisition of pluripotency, it is critical to identify cells that can be converted to pluripotent stem cells. For this purpose, scientists focused on unipotent primordial germ cells, which can be reprogrammed into pluripotent embryonic germ cells under defined conditions. [Biol Reprod] Abstract

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A*STAR Researchers Amongst Top Young Innovators in Asia-Pacific
A*STAR scholars Dr Jonathan Loh Yuin-Han and Dr Joel Yang have won the inaugural [email protected] Award that recognizes young innovators in the Asia-Pacific region, under the age of 35 years. [Agency for Science, Technology and Research (A*STAR)] Press Release

EMD Millipore and the Centre for Commercialization of Regenerative Medicine Collaborate to Optimize Conditions for Large-Scale Stem Cell Cultivation
EMD Millipore and the Centre for Commercialization of Regenerative Medicine announced a collaboration to develop optimized conditions for bioreactor-based cultivation of stem cells. [Centre for Commercialization of Regenerative Medicine] Press Release

Hughes to Add Up To 30 Investigators
For the first time in 5 years, the Howard Hughes Medical Institute (HHMI) is holding a general competition for a new round of up to 30 HHMI investigators. [ScienceInsider] Press Release
Putin Promises Science Boost
Vladimir Putin’s government will aim to establish several “world-class” research universities by 2020. Putin also promised a substantial increase in public funding of basic and applied research. [Russian Government, Russia] Press Release

Scientists Decry Spanish Cutbacks
Scientists are warning Spain’s government that its planned budget cuts and hiring freeze could be fatal for the nation’s science. [Investigación Digna, Spain] Press Release

No Ticket to Ride: U.K. Animal Rights Campaigners End Ferry Service for Lab Animals
Following a high-pressure campaign from animal rights activists, the final ferry company that carried research animals between the United Kingdom and Europe has stopped the service, academic funders announced. [National Anti-Vivisection Alliance, United Kingdom] Press Release

India’s Budget Plan Disappoints Scientists, Despite New Mission to Mars
The annual budget proposal presented to India’s parliament on 16 March by Finance Minister Pranab Mukherjee calls for the operating budgets for science to rise, on average, by about 5% in 2012-2013—less than what many scientists had expected. [Finance Minister, India] Press Release

Notice of Change in Participation of NIH Institutes and Centers in PAR-10-225 “Biomedical Technology Research Center (P41)” (NOT-OD-12-072) [National Institutes of Health, United States]
NEW The 2012 Stem Cell Discussion Forum
October 3, 2012
London, United Kingdom

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Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Embryonic Stem Cell Biology Technician (Kymab Ltd.)

Postdoctoral Position – Department of Biomedical Engineering (Tsinghua University School of Medicine)

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