N6-Methyladenosine Modification Destabilizes Developmental Regulators in Embryonic Stem Cells
Researchers identified two proteins, the putative N6-methyladenosine (m6A) MTase, methyltransferase-like 3 (Mettl3), and a related but uncharacterized protein Mettl14, that function synergistically to control m6A formation in mammalian cells. Knockdown of Mettl3 and Mettl14 in mouse embryonic stem cells led to similar phenotypes, characterized by lack of m6A RNA methylation and lost self-renewal capability. [Nat Cell Biol]
Abstract
Human Pluripotent Stem Cell Culture: Considerations for Maintenance, Expansion, and Therapeutics
The authors dissect human pluripotent stem cell growth components by comparing cell culture methods and identifying the benefits and pitfalls associated with each one. They further provided criteria, considerations, and suggestions to achieve optimal cell growth for human pluripotent stem cell expansion, differentiation, and use in future therapeutic applications. [Cell Stem Cell]
Abstract
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French Academy Decries Slide in Research Spending
The French Academy of Sciences has issued its strongest distress signal in decades to warn against the consequences of recent declines in government research spending. [Nature News]
Editorial
Europe Waters Down Transnational ‘Research Buddy’ Plan
Europe’s latest research-funding program includes, for the first time, money for ‘low-performing’ member states to set up research centers in their regions, in partnership with well-established institutions from other countries. But some observers were disappointed earlier this month when the European Union announced that the host countries will manage the centers – a rule that critics say could be challenging for fledgling institutions and perhaps perpetuate problems, such as nepotism, that have contributed to their poor performance in the first place. [Nature News]
Editorial
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